146 Beekman Street, date unknown. Constructed in 1885 as a smokehouse, the building at 146 Beekman has been tied to the NYC fishing industry, centered in this neighborhood, since its construction. By 1904, the building was also the headquarters of the New York Wholesale Fish Dealers Association. The painted signs on the facade that read "Fresh, Salt Smoked Fish" were in place by the 1930s, though likely were painted earlier. From 1914 to 1997 the building was home to the The Meyer and Thompson Smoked Fish Company. In 2004 a bar and cafe called Fresh Salt opened in the ground floor space and, despite damage endured during Hurricane Sandy in 2012, remains open, serving the neighborhood under its historic sign.

One of the most interesting structures in the State and National Register of Historic Places South Street Seaport Historic Districts is the Romanesque Revival building that was erected in 1885 for Ellen S. Auchmuty, a Schermerhorn family descendent. It was designed by George B. Post, an architect trained in the Beaux-Arts tradition, who also designed the old New York Times Building (1889) at Printing House Square, Bronx Borough Hall (1897), and the New York Stock Exchange (1904).