239 West 45th Street, unknown date.

Designed to the plans of architect C. Howard Crane, the intimate Music Box Theater was specifically constructed by composer Irving Berlin and producer Sam H. Harris to house Berlin's famed Music Box Revues. Though one of the smaller Broadway venues, with a seating capacity of only 860, its box seats are notable for being usually large and rounded.

After opening in 1921, the theatre hosted a new musical production annually until 1924, when it presented its first play, Cradle Snatchers, starring Humphrey Bogart. Notable playwrights have since found a home at the theatre, including William Inge in the 1950s, who had great success there with Picnic, Bus Stop, and The Dark at the Top of the Stairs.

The theatre was co-owned by Berlin's estate and the Shubert Organization until 2007, when the Shubert Organization assumed its full ownership.