The Knights of Pythias are a fraternal order (or perhaps better described as a secret society) established in 1864 by Justus H. Rathbone, an upstate New York-born actor, composer, and teacher. Inspired by Irish writer John Banim’s 1821 play 'Damon and Pythias,' Rathbone founded this order on the principles extolled in the drama: friendship, loyalty, and honor. And as with most secret societies, pageantry, rituals, and costumed ceremonies were also important aspects of membership.

The Manhattan lodge began assembling lots on West 70th Street for a clubhouse. Similar to other fraternal orders, the Knights of Pythias were interested in exotic architecture and turned to famed theatre architect Thomas Lamb for their Egyptian-themed home. Situated among the brownstones of an UWS side street, the tall building bedecked with cast stone reliefs, polychrome full-sized pharaoh figures, and an over-the-top entrance embellished with Egyptian symbols certainly was eye-catching. As ornate on the interior as the exterior, the building featured a gymnasium, a bowling alley, billiards room, 15 lodge rooms decorated in Aztec, Egyptian, and Moorish motifs, and two large auditoriums.

The building served not only the Knights but hosted sermons for large synagogues and churches, dances and concerts, and political conferences and meetings (including by the 1940s civil rights groups, the Socialist Labor, and the West Side Committee of American-Soviet Friendship). One of the main auditoriums also served as a recording studio for Decca Records in the 1950s.

New York Institute of Technology bought the foreclosed building in 1957 and discovered the kinds of strange props like wands and skeletons, both plastic and human! After functioning as an education space for NYIT, the building was converted into apartments between 1983 and 1986.