Public School 64, 1920.

Constructed between 1904 and 1906 to the designs of BOE architect C.B.J. Snyder, the French Renaissance Revival style building adheres to Snyder's usual H shaped design. When opened the school could hold 2,500 students and later had an annex constructed to accommodate a larger student body. As the populations of the East Village and Lower East Side declined in the 1970s and in the midst of the city's financial crisis, the school was closed in 1977.

Soon after closing the building became the home of a number of non-profits, including Adopt-A-Building (which trained and empowered residents of blighted neighborhoods to improve their own buildings) and CHARAS (a neighborhood center that fostered community-based urban ecology, arts and culture). After two decades of successful reactivation of the school space, the building was sold by the Giuliani administration to a developer in 1998. The groups were evicted in 2001. For the last 15 years, the building has continued to deteriorate. The school was landmarked in 2006 and various plans have been suggested for its redevelopment, including as dormitories, which most of the local community vehemently opposes. In the fall of 2017 current mayor De Blasio stated that the city wished to buy back the property, but the future of the building is unknown.