Built in 1911, the large building at 421 Hudson Street was originally the printing facility for Schweinler Press. Ten stories tall and occupying the fill blockfront, this building printed McClure's Magazine, The Ladies World, and Harper's Weekly. The press produced more than six million magazines monthly by 1913.

In the 1910s the printing firm became the target of a highly contested court case which challenged new labor laws that forbade female workers from toiling in "factories and mercantile establishments" between 10 P.M. and 6 A.M. In its first few years women had been hired for night work here. A New York State Court of Appeals ruling in 1915 upheld the ban of nighttime workers in "People v. Charles Schweinler Press."

In the 1970s the printing facility was converted into rental loft residences, a common transformation at the time in this neighborhood. In the late 1980s, a condo conversion was completed on 80% of the units. In 2013 the building was renovated completely and 60 condo units were put on the market.