The Ludlow Street Jail, New York City's 19th-century federal prison, opened in 1862 at the corner of Ludlow and Broome Streets. Intended as a prison for civil offenders, most inmates were debtors. The infamous Tammany Hall politician Boss Tweed was held at Ludlow Street, where he died of pneumonia in 1878, at the time unable to repay some $6 million of embezzled city funds. Victoria Woodhull, the first female presidential candidate, was also imprisoned for six months in 1872, accused of sending obscene material in the mail.

The jail closed in December 1927 and was subsequently demolished. Today, the Department of Education’s Seward Park Campus, built in 1929, occupies the site.