Grand Opera House, 1937.

Originally opened as Pike's Opera House in 1868, the building became the Grand Opera House the next year when it was purchased by James Fisk and Jay Gould. The repertoire was expanded beyond classic opera to include plays and light opera. Fisk's motivation for this was to create opportunity for his girlfriend, actress Josie Mansfield. He put her up in a nearby brownstone and gifted her cash and lavish jewels. The mansion also had a secret tunnel that led to the opera house and the upstairs offices of Fisk's Erie Railway. Fisk became the silent partner in an oil business run by a man named Ned Stokes. Stokes would became Mansfield's other lover and after much drama, including extortion, blackmail, libel lawsuits, and false charges of embezzlement, Stokes murdered Fisk, shooting him in 1872. Fisk lay in state at the opera house.

The theatre became a venue for more popular, working class productions, as the changing audience on the west side enjoyed a cheaper and less cultured repertoire. The building became an RKO theatre in 1938 after a renovation by theatre architect Thomas Lamb. Finally closed in preparation for demolition in June of 1960, the building was gutted by a fire in July of the same year.