Public School 16, 1920.

Originally School No. 16 of the Ninth Ward, the original section of the building was constructed in 1845, with additions erected in 1859 and later. The institution became Public School 16 by the turn of the 20th century, but was in bad condition by the 1920s. Reports of the facilities suggest “plumbing wet and foul" and “rooms small, dirty and dingy.” The school became a vocational campus in 1924 and during the Depression offered programs for unemployed adults.

In 1938 Mayor LaGuardia opened the building as the Food Trades Vocational High School, where pupils learned skills needed to become butchers, bakers, cafeteria workers, tea room hostesses and store clerks. LaGuardia wished to create an educational experience that would prepare children of poor immigrants for jobs that would remain necessary during times of economic depression. Later in the 1960s the school would add Maritime trades to its vocational offerings, becoming the Food and Maritime Trades High School. That institution moved into a new building in 1980 and this structure was put up for lease.

The building initially became the home of a number of social and community non-profits, including a few small LGBT-focused organizations. In 1983 the gay organizations and AIDS advocacy groups joined forces to purchase the building from the city, forming the Lesbian and Gay Community Services Center for that purpose. Over the last nearly 30 years the LGBT Community Center has become an integral organization in the gay community. It is a meeting place for community groups, the founding location of organizations such as Survivors of Transsexuality Anonymous and Gender Identity Project, and home to medical clinics and cultural programming.