24 East 54th Street was the original location of the Solomon R. Guggenheim Museum or the Museum of Non-Objective Painting as it was known at its founding.

These townhouses were replaced by an automobile showroom, likely in the 1920s, and in 1939 Peggy Guggenheim hired William Muschenheim to design the gallery space.

The museum showcased abstract paintings by American and European artists, such as Vasily Kandinsky and Rudolf Bauer. The museum remained here until it moved to a townhouse at 1017 Fifth Avenue in 1948.