"Brown Building, originally the Asch Building. Site of the Triangle Shirtwaist Company fire, 1975."

The Asch Building was built in 1900–01 by architect John Woolley, who designed it in the neo-Renaissance style. Because it was known for "fire-proof" rooms it was attractive to garment factories who were susceptible to fires. The Triangle Shirtwaist factory moved into the top three floors a year after the building was completed. It was on these top three floors (8th, 9th, and 10th) that the Triangle Fire occurred in March of 1911. Despite the fire hoses not being able to reach the floors that were on fire, and the massive loss of life, the building survived intact.

In 1916 New York University began to use the 8th floor for a library and classrooms. In 1929 the building was purchased by real estate developer and philanthropist Frederick Brown, donated to the university and renamed the Brown Building. Today the top floors are occupied by science classrooms and labs. There are a number of plaques at the base of the building that memorialize the fire and a larger memorial is currently being planned for the facade of the building.