City Hospital Blackwell's Island ca. 1896

The City Hospital on Blackwell's Island was originally called Penitentiary Hospital due to its nature as the hospital for the inmates of Blackwell's Penitentiary. Built in 1832, its name changed to the City Hospital Blackwell's Island after a fire caused its reconstruction in 1861. The new building, designed by James Renwick Jr. and constructed by inmates, served both the prisoners and the city's poorer inhabitants. Its name changed once again to Charity Hospital in 1873 due to the nature of its work. This, in turn, caused Blackwell's Island to be renamed Welfare Island in 1921. To complete all this renaming, the island itself was redesignated Roosevelt Island in 1973.

WIth many of the City Hospital's facilities growing obsolete, the City Hosptial was moved to Queens in the 1950s. The hospital building on Roosevelt Island was abandoned and left to ruin. Though it has fallen into disrepair, the Landmarks Preservation Committee granted it landmark status in 1975 for its important architectural details.