In the 1850s James Boorman Johnston, a wealthy real estate investor, had an idea. He wished to create a building that was designed specifically and solely for artists. He commissioned a young Richard Morris Hunt to bring his vision to life.

The resulting Tenth Street Studios were nothing much to look at from the outside, a somewhat simple three-story brick facade with large windows. But it was these windows that aided in the buildings innovative interior. The inside of the structure was laid out with a domed central gallery from which rooms radiated. Light flooded the studios from the large windows. The functional design was an instant success, with some of the spaced occupied before the building was even complete in mid-1858. Early tenants included painters Frederick Church and John LaFarge and Hunt himself, who started the first architecture school in the States from his studio here. Later famed artists William Merritt Chase and Winslow Homer lived and worked here.

The building remained true to its original form and function for more than half a century before an important, but ultimately non-disruptive change occurred. In 1920 the resident artists discovered that the owner wished to sell the building. They banded together and purchased it to hold off a commercial conversion or demolition. Saved for three more decades, the building was sold again in 1952 and razed four years later. A banal mid-century apartment building now stands in its place.