St. Francis Xavier R.C. Church, ca. 1895.

St. Francis Xavier Church was established in 1847 by Jesuits who came down from Fordham (then in Westchester) to start a Manhattan parish. The original building was a simple classical style building, constructed in the 1850s. In 1877 the original church was site of a false alarm panic after someone yelled 'fire' during a service. The ensuing stampede caused the death of seven people.

The first structure was demolished a year after this event, and a new church was built in a grand neo-Baroque style, completed in 1882. The tall church with an imposing granite-block facade was designed by well-known church architect Patrick Charles Keely. At the time of its completion it dwarfed most of the surrounding buildings. The interior too was designed in a colossal scale, with frescos, carved plaster and stone, arches, niches, and inlaid marble. A local newspaper in 1884 called the church "sumptuous and exhilarating.”