The Bowery Mission was established in 1879 and was the third rescue mission founded in the United States and the second in New York City. Since 1895 the mission has been operated by the Christian Herald Association. The mission occupied various buildings on the Bowery in its early years before moving into a permanent home at no. 227 in 1909.

The building at 227 Bowery was constructed in 1876 for an undertaker and manufacturer of coffins. When the Mission leased the building, it also commissioned work for the neo-Grec structure, including the addition of a Tudor Revival style mock half-timbered facade on the second floor. Fronted with four stained glass windows, a new Gothic Revival style chapel was installed behind the stained glass.

This religious-based organization was well-known for its bread lines. Numerous photographs taken during the Depression depict these queues. Today, the long-running service agency continues to provide food, shelter, employment, and medical assistance to homeless men (while also working with women and children at other locations).