St. Luke’s Chapel (Church of St. Luke in the Fields), ca. 1912. St. Luke’s was established in 1820 as a chapel of Trinity Church. Clement C. Moore, the first pastor, was responsible for planning the full-block complex that included a brick church building in the Federal style (1821-2), private burial ground, rectory, and surrounding townhouses. James N. Wells, a prolific builder, was responsible for construction. The popular moniker “St. Luke’s in-the-fields” arose from the character of the surrounding neighborhood at the time the church was built. Greenwich Village, though starting to be developed, still included considerable tracts of farmland. St. Luke’s has long had a reputation for philanthropy and ministry to the poor, including in recent decades, as the West Village community was hard-hit by the AIDS crisis. The AIDS Project of St. Luke’s, founded in 1987, provided food and care to New Yorkers, including many parishioners, affected by the crisis.

St. Luke's Chapel, October 21, 1935. The parish of St. Luke's was organized by Greenwich Village community members in the fall of 1820. They named the church after St. Luke, the physician, as a reference to the town's use as refuge from the yellow fever epidemics that plagued New York City during the summers. One of the church's founders was Clement Clark Moore, Oriental and Greek Literature scholar, author of "Twas the Night Before Christmas," and real estate developer of Chelsea. The church building was constructed between 1821 and 1822 on a plot of land donated by Trinity Church. In 1891 St. Luke's would become a chapel of Trinity Church. That relationship lasted through 1976, when St. Luke's once again became an independent parish of the Episcopal Church. A major fire in 1981destroyed much of the church building, but thought fundraising the structure was restored. Throughout the later 20th century the church became very active in community ministries, working with people with AIDS and at-risk LGBTQ youth.