The church tower was built in 1847 and the nave in 1870 to the designs of renowned architect Napoleon LeBrun. At the time of demolition in 2005 to make way for NYU’s Founder’s Hall, it was one of the only structures in all of New York City to have served what had been the city’s three main religions – it was originally a Protestant Church, later became the first home of Temple Beth El synagogue, and served as an Armenian National Shrine for the Roman Catholic Church. The demolished rectory (blue brick building) dated to the 1840’s.

120 East 12th Street, ca. 1975. The parish of St. Ann's was established in 1852 in the fashionable neighborhood near Bond Street, in what is now NoHo. The church began a habit of occupying churches that had been constructed for other, earlier congregations when they moved into a sanctuary on on East 8th Street, opposite Lafayette Place. In the 1860 the congregation had outgrown their space and also wished to constructed a school. The parish purchased the plot at 120 East 12th Street, which included a building constructed in 1847 for a Christian church, which had subsequently been converted to a synagogue. St. Ann's retained the original 1847 facade but demolished the rest of the structure to build their own church and an adjacent school. Dedicated on New Year’s Day, 1871, the church was a spectacular French Gothic style church, a fitting venue for one of the wealthiest congregations in the city. Over the next century the church remained a vibrant part of the community, becoming a shrine in 1929 (they held a relic of St. Ann, a bit of her finger bone). Re-established as St. Ann’s Armenian Rite Catholic Cathedral in the early 1980s, it was one of the last churches to have traditional, pre-Vatican II, Latin masses. The Archdiocese announced their intention to close the church and sell the property in 2003 and by the following year the doors were shut. Despite the efforts of preservationists and the community, the Landmarks Preservation Commission declined to designate the building. The lot was sold in 2005 with plans drawn up for a new 26-story NYU dorm. In the end all but the facade was demolished (supposedly as a concession to the preservationists) and the new tower was constructed. In the shadow of the tower is the disembodied front of the more than century and half old church.